We prepared a 41Ca carbonate, validating that radiological and elemental purity is sufficient for use as an oral dose in human tracer experiments. The original 41Ca stock was obtained in 1984 from Oak Ridge National Laboratory and purified by K. Nishiizumi [1], who provided an aliquot of the cleaned stock solution for our use in preparation of an oral dose material; an intravenous dosing solution was also prepared [2]. We measured the trace elemental purity of the stock solution, providing an upper limit of 0.41ng/Bq (7.5ng/nCi) dose for 67 examined elements. We also confirmed that the only radioactive element in the stock solution is 41Ca [2]. The prepared dose 41CaCO3 material was assayed for chemical purity and 41Ca content. We will present a detailed procedure for this chemical processing and validation.
This work was performed in part under the auspices of the U.S. Department of Energy by University of California Lawrence Livermore National Laboratory under Contract No. W-7405-Eng-48.
[1] Nishiizumi K, Caffee MW, DePaolo DJ. Preparation of 41Ca AMS standards. Nucl Instrum Methods Phys Res B. 2000;172:399-403.
[2] Fitzgerald RE, Hillegonds DJ, Burton DW. et al. 41Ca and accelerator mass spectrometry to monitor calcium metabolism in end stage renal disease patients. Clin Chem. 2005.
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